Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | OGT | O15294 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 4/20 | 0.35 |
| ▸ | NOS2 | P35228 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862683 | 0.73 | CA2 (0.36) | DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL6862505 | 0.72 | CA2 (0.35) | ALDH1A1HPGDDRD2HTR2A | |
| SCHEMBL6322472 | 0.70 | NQO2 (0.36) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL27003471 | 0.68 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL13015515 | 0.66 | CYP19A1 (0.38) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL23137519 | 0.64 | NOS1 (0.48) | MEN1KMT2AOGTNOS1NOS2 | |
| SCHEMBL3249002 | 0.64 | CYP1A2 (0.42) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL5311309 | 0.64 | OGT (0.46) | ALDH1A1MEN1KMT2AOGTNOS1 | |
| SCHEMBL522732 | 0.64 | NOS1 (0.44) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL2149020 | 0.63 | DAO (0.41) | KDM4EALDH1A1OGTNOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800648-B2 | SCHIZOPHRENIA, BIPOLAR DISORDERS, PARKINSON'S DISEASE; DRUG ABRUSE | WYETH | 2004-10-05 | — | — | US | disclosed |
| US-20030073697-A1 | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one | WYETH | 2003-04-17 | — | — | US | disclosed |
| WO-2002088142-A1 | ANTIPSYCHOTIC AMINOMETHYL DERIVATIVES OF 7,8-DIHYDRO-3H-1,6,9-TRIOXA-3-AZA-CYCLOPENTA[a]NAPHTHALEN-2-ONE | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073697-A1 | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one | SNCA, TUBA1C, SLC6A3 | KDM4E 2861/4885ALDH1A1 1985/4885HPGD 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.