Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.36 |
| ▸ | ITGAV | P06756 | 4/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862775 | 1.00 | MTNR1A (0.40) | MTNR1AMTNR1BALDH1A1CYP1A2ITGB3 | |
| SCHEMBL6862157 | 0.83 | MTNR1A (0.38) | MTNR1AMTNR1BALDH1A1CYP1A2ITGB3 | |
| SCHEMBL6857908 | 0.83 | MTNR1A (0.38) | MTNR1AMTNR1BALDH1A1CYP1A2ITGB3 | |
| SCHEMBL6857996 | 0.82 | MTNR1A (0.45) | MTNR1AMTNR1BCYP1A2ITGB3ITGAV | |
| SCHEMBL6857764 | 0.82 | MTNR1A (0.45) | MTNR1AMTNR1BCYP1A2ITGB3ITGAV | |
| SCHEMBL7516493 | 0.82 | MTNR1A (0.45) | MTNR1AMTNR1BCYP1A2ITGB3ITGAV | |
| SCHEMBL19984866 | 0.80 | CYP1A2 (0.49) | MTNR1AMTNR1BCYP1A2GAANOTUM | |
| SCHEMBL7442839 | 0.78 | SRD5A2 (0.44) | MTNR1AMTNR1BCYP1A2ITGB3ITGAV | |
| SCHEMBL6863347 | 0.76 | MTNR1A (0.36) | MTNR1AMTNR1BALDH1A1CYP1A2ITGB3 | |
| SCHEMBL6857814 | 0.74 | MTNR1A (0.36) | MTNR1AMTNR1BALDH1A1CYP1A2ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |