Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.33 |
| ▸ | ITGAV | P06756 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857814 | 0.89 | MTNR1A (0.36) | MTNR1AMTNR1BCASRNLRP3LMNA | |
| SCHEMBL6857908 | 0.86 | MTNR1A (0.38) | MTNR1AMTNR1BCASRNLRP3LMNA | |
| SCHEMBL6862157 | 0.86 | MTNR1A (0.38) | MTNR1AMTNR1BCASRNLRP3LMNA | |
| SCHEMBL6862777 | 0.76 | MTNR1A (0.40) | MTNR1AMTNR1BALDH1A1ITGB3ITGAV | |
| SCHEMBL6862775 | 0.76 | MTNR1A (0.40) | MTNR1AMTNR1BALDH1A1ITGB3ITGAV | |
| SCHEMBL7516493 | 0.75 | MTNR1A (0.45) | MTNR1AMTNR1BITGB3ITGAVITGB1 | |
| SCHEMBL6857764 | 0.75 | MTNR1A (0.45) | MTNR1AMTNR1BITGB3ITGAVITGB1 | |
| SCHEMBL6857996 | 0.75 | MTNR1A (0.45) | MTNR1AMTNR1BITGB3ITGAVITGB1 | |
| SCHEMBL19984866 | 0.75 | CYP1A2 (0.49) | MTNR1AMTNR1BPOLBCYP1A2HSD17B10 | |
| SCHEMBL7442839 | 0.74 | SRD5A2 (0.44) | MTNR1AMTNR1BITGB3ITGAVITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |