Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328397 | 0.81 | PPARD (0.53) | SMN1; SMN2ALDH1A1LMNAPPARDTDP1 | |
| SCHEMBL30354782 | 0.81 | ALDH1A1 (0.53) | MAP2K1SMN1; SMN2ALDH1A1LMNAPPARD | |
| SCHEMBL5570151 | 0.81 | ALDH1A1 (0.53) | MAP2K1SMN1; SMN2ALDH1A1LMNAPPARD | |
| SCHEMBL328394 | 0.81 | LMNA (0.53) | MAP2K1SMN1; SMN2ALDH1A1LMNAPPARD | |
| SCHEMBL15596867 | 0.80 | MAP2K1 (0.48) | MAP2K1LMNATDP1 | |
| SCHEMBL11483460 | 0.78 | LMNA (0.53) | SMN1; SMN2ALDH1A1LMNAPPARDTDP1 | |
| SCHEMBL432736 | 0.78 | SMN1; SMN2 (0.52) | MAP2K1SMN1; SMN2ALDH1A1LMNAPPARD | |
| SCHEMBL27572256 | 0.78 | PPARD (0.50) | SMN1; SMN2ALDH1A1LMNAPPARDTDP1 | |
| SCHEMBL11990011 | 0.78 | PPARD (0.50) | SMN1; SMN2ALDH1A1LMNAPPARDTDP1 | |
| SCHEMBL2644891 | 0.76 | LMNA (0.62) | SMN1; SMN2ALDH1A1LMNAPPARDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |