Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779090 | 0.83 | LMNA (0.53) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL6863054 | 0.81 | MAP2K1 (0.54) | LMNATDP1MAP2K1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11990105 | 0.80 | LMNA (0.49) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL11989288 | 0.80 | LMNA (0.49) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL14997983 | 0.80 | LMNA (0.49) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL15597016 | 0.78 | LTA4H (0.44) | TDP1MAP2K1LTA4H | |
| SCHEMBL13604562 | 0.75 | LMNA (0.44) | LMNATDP1ALDH1A1SMN1; SMN2FFAR4 | |
| SCHEMBL14021948 | 0.74 | LMNA (0.46) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL30535283 | 0.73 | LMNA (0.82) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL676142 | 0.73 | LMNA (0.82) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |