SCHEMBL6863514

SCHEMBL6863514

Cc1ccc(-c2nc3cc(C(=O)N(Cc4ccccc4)C(C)C)cc(N)n3n2)o1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 18/20 0.58
ATM Q13315 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6863745 0.90 ADORA2A (0.57) ADORA2AATM
SCHEMBL6869931 0.90 ADORA2A (0.72) ADORA2A
SCHEMBL6863226 0.89 ADORA2A (0.67) ADORA2A
SCHEMBL6869273 0.86 ADORA2A (0.56) ADORA2A
SCHEMBL6870373 0.84 ADORA2A (0.54) ADORA2AATM
SCHEMBL6873684 0.82 ADORA2A (0.46) ADORA2AATM
SCHEMBL6863238 0.82 ADORA2A (0.47) ADORA2AATM
SCHEMBL6868951 0.81 ADORA2A (0.56) ADORA2AATM
SCHEMBL6871231 0.81 ADORA2A (0.45) ADORA2AATM
SCHEMBL6869779 0.80 ADORA2A (0.46) ADORA2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1347974-B1 AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS HOFFMANN LA ROCHE (CH) 2004-11-03 EP disclosed