Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863238 | 0.83 | ADORA2A (0.47) | ADORA2ATP53SMN1; SMN2ATMMEN1 | |
| SCHEMBL6868951 | 0.82 | ADORA2A (0.56) | ADORA2ATP53ATMPARP1LMNA | |
| SCHEMBL6873684 | 0.81 | ADORA2A (0.46) | ADORA2ATP53SMN1; SMN2ATMMEN1 | |
| SCHEMBL6869273 | 0.81 | ADORA2A (0.56) | ADORA2A | |
| SCHEMBL6866915 | 0.80 | PSMB5 (0.51) | ADORA2ATP53SMN1; SMN2KMT2ALMNA | |
| SCHEMBL6863514 | 0.80 | ADORA2A (0.58) | ADORA2AATM | |
| SCHEMBL7142283 | 0.80 | ALOX15 (0.43) | ADORA2ASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL6868324 | 0.80 | NAMPT (0.46) | ADORA2AMEN1KMT2ALMNAHSD17B10 | |
| SCHEMBL6863745 | 0.80 | ADORA2A (0.57) | ADORA2AATMLMNAHTTNPSR1 | |
| SCHEMBL6871231 | 0.80 | ADORA2A (0.45) | ADORA2ATP53SMN1; SMN2ATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |