Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.53 |
| ▸ | MMP8 | P22894 | 6/20 | 0.53 |
| ▸ | MMP13 | P45452 | 5/20 | 0.53 |
| ▸ | MMP7 | P09237 | 4/20 | 0.53 |
| ▸ | MMP12 | P39900 | 4/20 | 0.53 |
| ▸ | MEP1B | Q16820 | 4/20 | 0.47 |
| ▸ | BMP1 | P13497 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 2/20 | 0.45 |
| ▸ | MMP16 | P51512 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 8/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328409 | 0.89 | MMP1 (0.38) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL6863608 | 0.83 | MMP1 (0.47) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL6864355 | 0.82 | MMP13 (0.47) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL328418 | 0.81 | MMP1 (0.45) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL328390 | 0.79 | MMP1 (0.43) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL328649 | 0.79 | MMP1 (0.44) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL328492 | 0.78 | MMP1 (0.42) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL6864397 | 0.78 | MMP1 (0.44) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL6863163 | 0.78 | MMP1 (0.44) | MMP1MMP8MMP13MMP7MMP12 | |
| SCHEMBL6865083 | 0.78 | MMP1 (0.48) | MMP1MMP8MMP13MMP7MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |