Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | SLC9A3 | P48764 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863736 | 0.89 | MMP1 (0.53) | MMP1MMP7MMP8MMP12MMP13 | |
| SCHEMBL6852278 | 0.87 | CACNA1H (0.40) | MMP1MMP7MMP8MMP12MMP13 | |
| SCHEMBL328416 | 0.81 | SMN1; SMN2 (0.35) | MMP1MMP7MMP8MMP12MMP13 | |
| SCHEMBL328408 | 0.81 | PDK2 (0.35) | MMP1MMP7MMP8MMP12MMP13 | |
| SCHEMBL6852280 | 0.78 | BDKRB1 (0.40) | SLC9A3MEN1KMT2AALDH1A1 | |
| SCHEMBL328403 | 0.77 | MEN1 (0.40) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL328414 | 0.77 | DAGLA (0.37) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6850664 | 0.76 | DAGLA (0.43) | MMP1MMP8MMP13SLC9A3ALDH1A1 | |
| SCHEMBL328548 | 0.76 | DAGLA (0.37) | SLC9A3KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL328661 | 0.76 | KMT2A (0.38) | KMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |