Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6871451 | 0.90 | ADORA2A (0.66) | ADORA2A | |
| SCHEMBL6863095 | 0.89 | ADORA2A (0.67) | ADORA2A | |
| SCHEMBL6869719 | 0.85 | ADORA2A (0.61) | ADORA2A | |
| SCHEMBL6863180 | 0.83 | ADORA2A (0.58) | ADORA2A | |
| SCHEMBL6867105 | 0.81 | ADORA2A (0.66) | ADORA2A | |
| SCHEMBL6863389 | 0.81 | NPC1 (0.47) | ADORA2AMEN1MAPTHPGDALOX15 | |
| SCHEMBL6871702 | 0.80 | ADORA2A (0.77) | ADORA2A | |
| SCHEMBL6869813 | 0.80 | ADORA2A (0.44) | ADORA2AMEN1MAPTHPGDALOX15 | |
| SCHEMBL6871980 | 0.80 | ADORA2A (0.79) | ADORA2A | |
| SCHEMBL6869714 | 0.79 | ADORA2A (0.43) | ADORA2AMEN1MAPTHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |