Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863785 | 0.88 | ADORA2A (0.44) | ADORA2AALDH1A1RAB9A | |
| SCHEMBL6863389 | 0.83 | NPC1 (0.47) | ADORA2AMAPTHPGDPOLBPTAFR | |
| SCHEMBL6871451 | 0.82 | ADORA2A (0.66) | ADORA2A | |
| SCHEMBL6870443 | 0.81 | LMNA (0.45) | ADORA2AMAPTHPGDALDH1A1NPC1 | |
| SCHEMBL6869813 | 0.80 | ADORA2A (0.44) | ADORA2AMAPTHPGDPOLBNPC1 | |
| SCHEMBL6863074 | 0.80 | ADORA2A (0.62) | ADORA2AMAPTHPGDALDH1A1POLB | |
| SCHEMBL6870495 | 0.80 | POLB (0.42) | ADORA2AMAPTHPGDALDH1A1POLB | |
| SCHEMBL6869707 | 0.79 | KIT (0.44) | ADORA2AHPGDALDH1A1POLBNPC1 | |
| SCHEMBL6863742 | 0.79 | ADORA2A (0.52) | ADORA2AMAPTHPGDPOLBMEN1 | |
| SCHEMBL6863095 | 0.79 | ADORA2A (0.67) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |