Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HINT1 | P49773 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858664 | 0.90 | HPGD (0.54) | HPGDHINT1ADORA2AADORA3NT5E | |
| SCHEMBL2533734 | 0.87 | HPGD (0.51) | HPGDHINT1ADORA2AADORA3NT5E | |
| SCHEMBL31011272 | 0.87 | HPGD (0.50) | HPGDHINT1ADORA2AADORA3NT5E | |
| SCHEMBL23883607 | 0.86 | HPGD (0.50) | HPGDHINT1ADORA2AADORA3NT5E | |
| SCHEMBL6512797 | 0.84 | HPGD (0.48) | HPGDHINT1ADORA2AADORA3NT5E | |
| SCHEMBL31225342 | 0.84 | ADORA2A (0.51) | HPGDHINT1ADORA2AADORA3NT5E | |
| SCHEMBL18636462 | 0.84 | ADORA2A (0.51) | HPGDHINT1ADORA2AADORA3NT5E | |
| SCHEMBL6515281 | 0.84 | HPGD (0.47) | HPGDHINT1ADORA2AADORA3NT5E | |
| 2'-B-Methyl-Guanosine SCHEMBL14853673 | 0.83 | ADORA2A (0.65) | HPGDHINT1ADORA2AADORA3NT5E | |
| 2'-B-Methyl-Guanosine SCHEMBL21007207 | 0.83 | ADORA2A (0.65) | HPGDHINT1ADORA2AADORA3NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6111094-A | OLIGONUCLEOTIDE WITH AT LEAST ONE 2' MODIFICATION; FOR MODULATION OF HUMAN INTRACELLULAR ADHESION MOLECULE-1; ANTIINFLAMMATORY/ANTICARCINOGENIC/ ANTIMETASTASIS AGENTS; ANTIARTHRITIC AGENTS; TREATMENT OF SKIN DISORDERS | ISIS PHARMACEUTICALS INC. (US) | 2000-08-29 | — | — | US | claimed |
| WO-2022150369-A1 | COMPOUNDS FOR THE TREATMENT OF BATTEN DISEASE | EXICURE OPERATING COMPANY (US) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022147541-A1 | COMPOUNDS FOR MODULATING SCN9A EXPRESSION | EXICURE OPERATING COMPANY (US) | 2022-07-07 | — | — | WO | disclosed |
| US-6800751-B2 | ALKYLATION OF 2'-HYDROXY GROUP OF RIBONUCLEOSIDE PROTECTED WITH INVENTIVE SILYLATING AGENTS IN PRESENCE OF EXCESS OF MILD HINDERED BASE MAY BE CARRIED OUT WITHOUT PROTECTING EXOCYCLIC AMINE AND OXO FUNCTIONALITIES OF NUCLEOBASES | ISIS PHARMACEUTICALS, INC. | 2004-10-05 | — | — | US | disclosed |
| US-20030225262-A1 | Reagent and process for protecting active groups | IONIS PHARMACEUTICALS, INC. | 2003-12-04 | — | — | US | disclosed |
| WO-2003087053-A2 | REAGENT AND PROCESS FOR PROTECTING NUCLEOSIDE ACTIVE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225262-A1 | Reagent and process for protecting active groups | TRDMT1, SBDS, DIMT1 | HPGD 367/4885HINT1 556/4885ADORA2A 1249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.