Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 5/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 10/20 | 0.42 |
| ▸ | CX3CR1 | P49238 | 9/20 | 0.41 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864817 | 0.89 | PAK4 (0.63) | PAK4CXCR2CX3CR1MEN1ALDH1A1 | |
| SCHEMBL6864976 | 0.88 | PAK4 (0.62) | PAK4CXCR2CX3CR1MEN1ALDH1A1 | |
| SCHEMBL6866495 | 0.85 | PAK4 (0.58) | PAK4CXCR2CX3CR1MEN1ALDH1A1 | |
| SCHEMBL6991839 | 0.85 | PAK4 (0.57) | PAK4CXCR2CX3CR1CYP1A2MAPT | |
| SCHEMBL6864085 | 0.84 | CX3CR1 (0.55) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6865683 | 0.82 | CXCR2 (0.57) | PAK4CXCR2CX3CR1MEN1ALDH1A1 | |
| SCHEMBL6866675 | 0.82 | CXCR2 (0.66) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6865593 | 0.81 | CXCR2 (0.67) | PAK4CXCR2CX3CR1 | |
| SCHEMBL6866196 | 0.80 | CX3CR1 (0.69) | CXCR2CX3CR1 | |
| SCHEMBL6859575 | 0.80 | PAK4 (0.56) | PAK4CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |