Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 5/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766397 | 0.81 | CSNK1A1 (0.51) | PGK1LRRK2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11176262 | 0.74 | LRRK2 (0.47) | PGK1AURKALRRK2SYK | |
| SCHEMBL20630523 | 0.70 | CSNK1A1 (0.41) | AURKASYK | |
| SCHEMBL22688500 | 0.70 | PDGFRB (0.41) | AURKALRRK2MAPK8ALDH1A1 | |
| SCHEMBL11165586 | 0.69 | PGK1 (0.46) | PGK1SMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL22110391 | 0.69 | NPC1 (0.52) | PGK1LRRK2KDM4EALDH1A1HPGD | |
| SCHEMBL4765894 | 0.69 | CSNK1A1 (0.50) | PGK1AURKALRRK2SYKKDM4E | |
| SCHEMBL2025331 | 0.68 | SMN1; SMN2 (0.45) | PGK1AURKALRRK2SMN1; SMN2POLB | |
| SCHEMBL29313773 | 0.68 | CCNA2 (0.46) | AURKALRRK2SYKKDM4EALDH1A1 | |
| SCHEMBL4768640 | 0.68 | POLB (0.49) | PGK1LRRK2SMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397351-A1 | PYRIMIDINE, TRIAZINE AND PYRAZINE DERIVATIVES AS GLUTAMATE RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098864-A1 | PYRIMIDINE, TRIAZINE AND PYRAZINE DERIVATIVES AS GLUTAMATE RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-12-12 | — | — | WO | disclosed |