Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 14/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19152217 | 0.83 | L3MBTL1 (0.66) | MAPTPDE5AADORA3KCNH2L3MBTL1 | |
| SCHEMBL7810924 | 0.81 | LMNA (0.46) | MAPTL3MBTL1 | |
| SCHEMBL5774181 | 0.80 | PDE5A (0.54) | PDE5AADORA3KCNH2 | |
| SCHEMBL6762762 | 0.80 | MAPT (0.50) | MAPTPDE5AADORA3KCNH2L3MBTL1 | |
| SCHEMBL174998 | 0.80 | MAPT (0.53) | MAPTPDE5AADORA3KCNH2L3MBTL1 | |
| SCHEMBL6865363 | 0.80 | MAPT (0.50) | MAPTPDE5AADORA3KCNH2L3MBTL1 | |
| SCHEMBL18496415 | 0.79 | PDE5A (0.59) | PDE5AADORA3KCNH2 | |
| SCHEMBL19126778 | 0.78 | ADORA3 (0.50) | MAPTPDE5AADORA3KCNH2L3MBTL1 | |
| SCHEMBL175370 | 0.78 | ATM (0.53) | MAPTPDE5AADORA3KCNH2ATM | |
| SCHEMBL6762615 | 0.77 | MAPT (0.47) | MAPTPDE5AADORA3KCNH2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944631-B1 | NOVEL SUBSTITUTED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CARDIOCIRCULATORY DISEASES | BAYER HEALTHCARE AG (DE) | 2004-02-18 | — | — | EP | disclosed |
| US-6451805-B1 | Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 2002-09-17 | — | — | US | disclosed |
| EP-0944631-A1 | NOVEL SUBSTITUTED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CARDIOCIRCULATORY DISEASES | BAYER AG (DE) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023619-A1 | NOVEL SUBSTITUTED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CARDIOCIRCULATORY DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-04 | — | — | WO | disclosed |