Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 18/20 | 0.56 |
| ▸ | BCHE | P06276 | 14/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29389671 | 0.83 | KDM4E (0.61) | ACHEBCHE | |
| SCHEMBL30914704 | 0.82 | ACHE (0.60) | ACHEBCHE | |
| Hydrochloric Acid SCHEMBL7566412 | 0.80 | ACHE (0.58) | ACHEBCHE | |
| Iodide SCHEMBL17187192 | 0.80 | KDM4E (0.65) | ACHEBCHE | |
| SCHEMBL31405822 | 0.80 | BCHE (0.46) | ACHEBCHE | |
| Iodide SCHEMBL10815828 | 0.79 | ACHE (0.66) | ACHEBCHE | |
| SCHEMBL31405824 | 0.78 | BCHE (0.70) | ACHEBCHE | |
| Bromide SCHEMBL4620833 | 0.78 | NPC1 (0.55) | ACHEBCHE | |
| Bromide SCHEMBL17187182 | 0.78 | ACHE (0.55) | ACHEBCHE | |
| SCHEMBL22034130 | 0.77 | ACHE (0.68) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806089-B1 | QUANTITATIVE ANALYSIS; DOES NOT REQUIRE THE SENSING FLUOROPHORE TO DISPLAY A CHANGE IN LIFETIME; SELF-CALIBRATING | UNIVERSITY OF MARYLAND, BALTIMORE | 2004-10-19 | — | — | US | claimed |
| WO-2000014515-A9 | LOW FREQUENCY MODULATION SENSORS USING NANOSECOND FLUOROPHORES | UNIV MARYLAND (US) | 2000-08-31 | — | — | WO | claimed |
| WO-2000014515-A1 | LOW FREQUENCY MODULATION SENSORS USING NANOSECOND FLUOROPHORES | UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 2000-03-16 | — | — | WO | claimed |
| US-6806089-B1 | QUANTITATIVE ANALYSIS; DOES NOT REQUIRE THE SENSING FLUOROPHORE TO DISPLAY A CHANGE IN LIFETIME; SELF-CALIBRATING | UNIVERSITY OF MARYLAND, BALTIMORE | 2004-10-19 | — | — | US | disclosed |
| WO-2000014515-A9 | LOW FREQUENCY MODULATION SENSORS USING NANOSECOND FLUOROPHORES | UNIV MARYLAND (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-2000014515-A1 | LOW FREQUENCY MODULATION SENSORS USING NANOSECOND FLUOROPHORES | UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 2000-03-16 | — | — | WO | disclosed |