Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.38 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.38 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PPM1A | P35813 | 4/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4619723 | 0.78 | KDM4E (0.57) | NPC1RAB9AKDM4ELMNAPOLB | |
| Bromide SCHEMBL6865008 | 0.78 | ACHE (0.56) | ACHEBCHE | |
| SCHEMBL16865134 | 0.76 | KDM4E (0.55) | NPC1RAB9AKDM4ELMNAPOLB | |
| Bromide SCHEMBL4619927 | 0.71 | LMNA (0.44) | NPC1RAB9APPM1AKDM4ELMNA | |
| Bromide SCHEMBL4619930 | 0.71 | LMNA (0.44) | NPC1RAB9APPM1AKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL11597659 | 0.70 | NPC1 (0.60) | NPC1RAB9APPM1AKDM4ELMNA | |
| SCHEMBL12160925 | 0.70 | NPC1 (0.55) | NPC1RAB9AGRIN1GRIN2AKDM4E | |
| SCHEMBL2796426 | 0.68 | NPC1 (0.54) | NPC1RAB9AGRIN1GRIN2AKDM4E | |
| SCHEMBL18799222 | 0.66 | KDM4E (0.52) | NPC1RAB9AKDM4ELMNAPOLB | |
| Bromide SCHEMBL50240 | 0.65 | KDM4E (0.55) | NPC1RAB9AKDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080124732-A1 | METHOD FOR OPTICAL MEASUREMENT OF MULTI-STRANDED NUCLEIC ACID | FUJIFILM CORPORATION | 2008-05-29 | — | — | US | disclosed |
| EP-1889880-A2 | Method for optical measurement of multi-stranded nucleic acid | FUJIFILM Corporation (JP) | 2008-02-20 | — | — | EP | disclosed |
| EP-1362894-B1 | Method for optical measurement of multi-stranded nucleic acid using cyanine dyes | FUJIFILM CORP (JP) | 2007-12-19 | — | — | EP | disclosed |
| US-20050112770-A1 | Method for optical measurement of multi-stranded nucleic acid | FUJI PHOTO FILM CO., LTD. | 2005-05-26 | — | — | US | disclosed |
| EP-1362894-A2 | Method for optical measurement of multi-stranded nucleic acid using cyanine dyes | FUJI PHOTO FILM CO., LTD. (JP) | 2003-11-19 | — | — | EP | disclosed |