Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687213 | 0.91 | MAPT (0.43) | MAPTTP53RXFP1PTGER3SMN1; SMN2 | |
| SCHEMBL686808 | 0.91 | CTSA (0.42) | MAPTTP53RXFP1PTGER3L3MBTL1 | |
| SCHEMBL687096 | 0.90 | MEN1 (0.43) | MAPTTP53RXFP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL688254 | 0.87 | SMN1; SMN2 (0.44) | MAPTTP53RXFP1PTGER3SMN1; SMN2 | |
| SCHEMBL688409 | 0.86 | PPARG (0.42) | MAPTTP53RXFP1PTGER3L3MBTL1 | |
| SCHEMBL688345 | 0.86 | MEN1 (0.41) | MAPTTP53RXFP1PTGER3L3MBTL1 | |
| SCHEMBL688170 | 0.86 | PTGER3 (0.41) | MAPTTP53RXFP1PTGER3SMN1; SMN2 | |
| SCHEMBL687155 | 0.82 | PTGER3 (0.44) | PTGER3SMN1; SMN2ALDH1A1CYP26A1KDM4E | |
| SCHEMBL687879 | 0.82 | CTSA (0.41) | MAPTTP53RXFP1PTGER3SMN1; SMN2 | |
| SCHEMBL688519 | 0.82 | PTGER3 (0.46) | PTGER3SMN1; SMN2ALDH1A1CYP26A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |