Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | KDM1A | O60341 | 7/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15423268 | 0.74 | PIM1 (0.63) | SIGMAR1KDM1ASLC22A1PRNPTP53 | |
| SCHEMBL29022154 | 0.73 | PIM1 (0.61) | SIGMAR1KDM1ASLC22A1PRNPTP53 | |
| SCHEMBL24980301 | 0.73 | KDM1A (0.57) | SIGMAR1KDM1ALMNAMAPTPIM1 | |
| SCHEMBL9427386 | 0.72 | SIGMAR1 (0.61) | SIGMAR1LMNA | |
| SCHEMBL765775 | 0.72 | PTGS1 (0.64) | SIGMAR1KDM1ASLC22A1PRNPTP53 | |
| SCHEMBL208025 | 0.71 | PIM1 (0.79) | SIGMAR1KDM1ASLC22A1PRNPTP53 | |
| SCHEMBL30950673 | 0.71 | KDM1A (0.55) | SIGMAR1KDM1ASLC22A1PRNPTP53 | |
| Ammonia Solution, Strong SCHEMBL22186864 | 0.70 | KDM1A (0.57) | SIGMAR1KDM1ASLC22A1PRNPTP53 | |
| SCHEMBL2794487 | 0.70 | SIGMAR1 (0.59) | SIGMAR1 | |
| SCHEMBL2794958 | 0.70 | SIGMAR1 (0.59) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030032801-A1 | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2003-02-13 | — | — | US | claimed |
| WO-2002089810-A1 | CHEMOSENSITIZING AGENTS AGAINST CHLOROQUINE RESISTANT PLASMODIUM FALCIPARUM AND METHODS OF MAKING AND USING THEREOF | UNITED STATES ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2002-11-14 | — | — | WO | claimed |
| US-6800618-B2 | PHENOTHIAZINE OR IMINODIBENZYL DERIVATIVES AS ANTIMALARIAL AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2004-10-05 | — | — | US | disclosed |
| US-20030032801-A1 | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2003-02-13 | — | — | US | disclosed |
| WO-2002089810-A1 | CHEMOSENSITIZING AGENTS AGAINST CHLOROQUINE RESISTANT PLASMODIUM FALCIPARUM AND METHODS OF MAKING AND USING THEREOF | UNITED STATES ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030032801-A1 | Chemosensitizing agents against chloroquine resistant plasmodium falciparum and methods of making and using thereof | ABCC1, SLC11A2, G6PD | SIGMAR1 174/4885KDM1A 1966/4885SLC22A1 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.