Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6465834 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RAURKADAPK3 | |
| SCHEMBL6875706 | 0.90 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RAURKBADRA1A | |
| SCHEMBL6875712 | 0.90 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RAURKBADRA1A | |
| SCHEMBL6872838 | 0.90 | ADRA2A (0.45) | MCHR1ADRA2ANPY5RTUBB3ACHE | |
| SCHEMBL6872840 | 0.90 | ADRA2A (0.45) | MCHR1ADRA2ANPY5RTUBB3ACHE | |
| SCHEMBL6877407 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RTUBB3ADRA1A | |
| SCHEMBL6877399 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RTUBB3ADRA1A | |
| SCHEMBL6879461 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RTUBB3 | |
| SCHEMBL6879458 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RTUBB3 | |
| SCHEMBL6869384 | 0.89 | AURKA (0.42) | MCHR1ADRA2AAURKADAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |