Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879458 | 1.00 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6867919 | 0.92 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6867923 | 0.92 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6877407 | 0.91 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RMAPTKMT2A | |
| SCHEMBL6877399 | 0.91 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RMAPTKMT2A | |
| SCHEMBL6465834 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RTUBB3 | |
| SCHEMBL6866557 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RTUBB3 | |
| SCHEMBL6873984 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RTUBB3ALDH1A1 | |
| SCHEMBL6873979 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RTUBB3ALDH1A1 | |
| SCHEMBL6877468 | 0.86 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |