Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29715383 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| SCHEMBL32677077 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| SCHEMBL1491696 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| SCHEMBL1491698 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| SCHEMBL29707282 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL30665771 | 0.98 | KDM4E (0.55) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL10749367 | 0.98 | KDM4E (0.55) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL8724704 | 0.98 | KDM4E (0.55) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL14059291 | 0.98 | KDM4E (0.55) | KDM4EALDH1A1CYP1A2GAACYP2D6 | |
| SCHEMBL27478435 | 0.85 | MEN1 (0.47) | KMT2AMEN1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162365-A1 | SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-29 | — | — | WO | disclosed |
| US-6815440-B2 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS IN THE COURSE OF WHICH IS INVOLVED AN INCREASED ACTIVITY OF MATRIX-DEGRADING METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-11-09 | — | — | US | disclosed |
| US-20030176432-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | AVENTIS PHARMA DEUTSCHLAND GMBH. | 2003-09-18 | — | — | US | disclosed |
| US-6573277-B2 | Metalloproteinase inhibitor | HOECHST AKTIENGESELLSCHAFT (DE) | 2003-06-03 | — | — | US | disclosed |
| US-20010011134-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | HOECHST AKTIENGESELLSCHAFT | 2001-08-02 | — | — | US | disclosed |
| US-6207672-B1 | FOR TREATMENT OF CONNECTIVE TISSUE DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010011134-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | MMP1, MMP2, HPGD | KDM4E 3576/4885ALDH1A1 45/4885CYP1A2 47/4885 |
| US-20030176432-A1 | Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acids | MMP1, MMP2, HPGD | KDM4E 3576/4885ALDH1A1 45/4885CYP1A2 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.