Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345465 | 0.89 | CDK5 (0.49) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5342710 | 0.86 | CDK5 (0.52) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5345581 | 0.86 | CDK5 (0.47) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5348467 | 0.84 | CDK5 (0.52) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5342649 | 0.83 | CDK5 (0.52) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5354577 | 0.82 | CDK5 (0.53) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5342249 | 0.82 | CDK5 (0.43) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5342113 | 0.82 | CDK5 (0.46) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5345065 | 0.81 | CDK5 (0.41) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5345480 | 0.81 | CDK5 (0.45) | CDK5CDK5R1ROCK1DYRK1ACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | CDK5 64/4885CDK5R1 359/4885ROCK1 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.