Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867249 | 1.00 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RAPLNRKMT2A | |
| SCHEMBL6873945 | 0.93 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RKMT2AMAPT | |
| SCHEMBL6457972 | 0.93 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RKMT2AMAPT | |
| SCHEMBL6879762 | 0.91 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RMAPTFLT3 | |
| SCHEMBL6879769 | 0.91 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RMAPTFLT3 | |
| SCHEMBL6878131 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RKMT2AMEN1 | |
| SCHEMBL6874201 | 0.89 | ADRA2A (0.45) | MCHR1ADRA2AAPLNRKMT2AMEN1 | |
| SCHEMBL6874187 | 0.89 | ADRA2A (0.45) | MCHR1ADRA2AAPLNRKMT2AMEN1 | |
| SCHEMBL6878137 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RKMT2AMEN1 | |
| SCHEMBL6873512 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RTSHRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |