Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874187 | 1.00 | ADRA2A (0.45) | ADRA2AMCHR1TSHRKMT2AMEN1 | |
| SCHEMBL6459434 | 0.93 | MCHR1 (0.41) | ADRA2AMCHR1TSHRKMT2AMEN1 | |
| SCHEMBL6875761 | 0.93 | MCHR1 (0.41) | ADRA2AMCHR1TSHRKMT2AMEN1 | |
| SCHEMBL6867249 | 0.89 | MCHR1 (0.48) | ADRA2AMCHR1TSHRKMT2AMEN1 | |
| SCHEMBL6867254 | 0.89 | MCHR1 (0.48) | ADRA2AMCHR1TSHRKMT2AMEN1 | |
| SCHEMBL6873962 | 0.89 | ADRA2A (0.45) | ADRA2AMCHR1KMT2AMEN1KDM4E | |
| SCHEMBL6873966 | 0.89 | ADRA2A (0.45) | ADRA2AMCHR1KMT2AMEN1KDM4E | |
| SCHEMBL6876322 | 0.86 | ADRA2A (0.42) | ADRA2AMCHR1KMT2AMEN1MAPT | |
| SCHEMBL6876315 | 0.86 | ADRA2A (0.42) | ADRA2AMCHR1KMT2AMEN1MAPT | |
| SCHEMBL6460350 | 0.84 | ADRA2A (0.48) | ADRA2AMCHR1C5AR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |