Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 16/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596021 | 0.82 | PIK3C3 (0.49) | L3MBTL1 | |
| SCHEMBL6869709 | 0.78 | ALDH1A1 (0.53) | ADORA3ADORA2AADORA1ADORA2BL3MBTL1 | |
| SCHEMBL16464591 | 0.77 | PTK2 (0.50) | CYP1A2 | |
| SCHEMBL23326683 | 0.75 | ADORA3 (0.44) | ADORA3ADORA2ACYP1A2MAPK8MAPK9 | |
| SCHEMBL29861524 | 0.75 | ADORA3 (0.44) | ADORA3ADORA2ACYP1A2MAPK8MAPK9 | |
| SCHEMBL361909 | 0.74 | MLYCD (0.42) | — | |
| SCHEMBL29981147 | 0.74 | MEN1 (0.44) | — | |
| SCHEMBL23412501 | 0.74 | MEN1 (0.44) | — | |
| SCHEMBL19330134 | 0.73 | KDM4E (0.56) | L3MBTL1CYP1A2 | |
| SCHEMBL1367620 | 0.73 | MLYCD (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| CN-1486314-A | Aminotriazolopyridine derivatives as adenosine receptor ligands | - | 2004-03-31 | — | — | CN | disclosed |
| EP-1347974-A1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |
| WO-2002048145-A1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-20 | — | — | WO | disclosed |