Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.60 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.60 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120329 | 0.85 | GABRA1 (0.60) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL14803828 | 0.85 | GABRA1 (0.45) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL6867476 | 0.81 | GABRA1 (0.57) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL6868305 | 0.79 | GABRA1 (0.66) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| Amidate SCHEMBL22502728 | 0.77 | GABRA1 (0.97) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL14818825 | 0.76 | GABRA1 (0.56) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| Etomidate SCHEMBL39487 | 0.75 | GABRA1 (1.00) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| Amidate SCHEMBL39485 | 0.75 | GABRA1 (1.00) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| S-Etomidate SCHEMBL39486 | 0.75 | GABRA1 (1.00) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| Amidate SCHEMBL1817757 | 0.75 | GABRA1 (1.00) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187421-B2 | Etomidate analogues that do not inhibit adrenocortical steroid synthesis | THE GENERAL HOSPITAL CORPORATION (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150011603-A1 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS | THE GENERAL HOSPITAL CORPORATION (US) | 2015-01-08 | — | — | US | disclosed |
| EP-2451779-B1 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS | GEN HOSPITAL CORP (US) | 2014-09-03 | — | — | EP | disclosed |
| US-8765973-B2 | Etomidate analogues that do not inhibit adrenocortical steroid synthesis | THE GENERAL HOSPITAL CORPORATION (US) | 2014-07-01 | — | — | US | disclosed |
| US-20130079381-A1 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS | NIH - DEITR | 2013-03-28 | — | — | US | disclosed |
| WO-2011005969-A2 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS | THE GENERAL HOSPITAL CORPORATION (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011603-A1 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS | OPRL1, NR3C2, NR3C1 | GABRA1 824/4885GABRB2 845/4885CYP1A2 25/4885 |
| US-20130079381-A1 | ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS | OPRL1, NR3C2, NR3C1 | GABRA1 824/4885GABRB2 845/4885CYP1A2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.