Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867578 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6875039 | 0.90 | EPHX1 (0.51) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6875033 | 0.90 | EPHX1 (0.51) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6880005 | 0.90 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6879998 | 0.90 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6875715 | 0.89 | PKM (0.45) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6875718 | 0.89 | PKM (0.45) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6875707 | 0.89 | MCHR1 (0.44) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6458561 | 0.89 | MCHR1 (0.50) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A | |
| SCHEMBL6458549 | 0.89 | MCHR1 (0.50) | SMN1; SMN2RAB9ANPC1MCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |