Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875718 | 1.00 | PKM (0.45) | PKMLMNAHTTALDH1A1ADRA2A | |
| SCHEMBL6866804 | 0.91 | LMNA (0.60) | PKMLMNAHTTALDH1A1ADRA2A | |
| SCHEMBL6866808 | 0.91 | LMNA (0.60) | PKMLMNAHTTALDH1A1ADRA2A | |
| SCHEMBL7044566 | 0.90 | BCHE (0.46) | PKMLMNAHTTALDH1A1ADRA2A | |
| SCHEMBL6868667 | 0.90 | ALPL (0.52) | PKMLMNAHTTALDH1A1ADRA2A | |
| SCHEMBL7044564 | 0.90 | BCHE (0.46) | PKMLMNAHTTALDH1A1ADRA2A | |
| SCHEMBL6868673 | 0.90 | ALPL (0.52) | PKMLMNAHTTALDH1A1ADRA2A | |
| SCHEMBL6867573 | 0.89 | SMN1; SMN2 (0.57) | LMNAHTTALDH1A1ADRA2AMCHR1 | |
| SCHEMBL6867578 | 0.89 | SMN1; SMN2 (0.57) | LMNAHTTALDH1A1ADRA2AMCHR1 | |
| SCHEMBL6868978 | 0.89 | LMNA (0.55) | PKMLMNAALDH1A1ADRA2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |