Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867585 | 1.00 | MCHR1 (0.45) | MCHR1OPRM1OPRD1ITGB3ITGAV | |
| SCHEMBL6868405 | 0.90 | MCHR1 (0.44) | MCHR1ITGB3ITGAVNPY5RADRA2A | |
| SCHEMBL6868396 | 0.90 | MCHR1 (0.44) | MCHR1ITGB3ITGAVNPY5RADRA2A | |
| SCHEMBL6461455 | 0.90 | MCHR1 (0.44) | MCHR1ITGB3ITGAVNPY5RADRA2A | |
| SCHEMBL6461446 | 0.90 | MCHR1 (0.44) | MCHR1ITGB3ITGAVNPY5RADRA2A | |
| SCHEMBL27653033 | 0.90 | SIGMAR1 (0.50) | MCHR1OPRM1OPRD1TDP1CCNA2 | |
| SCHEMBL6879386 | 0.89 | MCHR1 (0.47) | MCHR1ITGB3ITGAVNPY5RADRA2A | |
| SCHEMBL6879382 | 0.89 | MCHR1 (0.47) | MCHR1ITGB3ITGAVNPY5RADRA2A | |
| SCHEMBL6875638 | 0.86 | MCHR1 (0.46) | MCHR1OPRM1ITGB3ITGAVNPY5R | |
| SCHEMBL6875635 | 0.86 | MCHR1 (0.46) | MCHR1OPRM1ITGB3ITGAVNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |