Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867647 | 1.00 | ADRA2A (0.44) | ADRA2AMCHR1MAPTMEN1NPC1 | |
| SCHEMBL6878472 | 0.94 | ADRA2A (0.44) | ADRA2AMCHR1MAPTMEN1KMT2A | |
| SCHEMBL6878467 | 0.94 | ADRA2A (0.44) | ADRA2AMCHR1MAPTMEN1KMT2A | |
| SCHEMBL6873049 | 0.92 | ALDH1A1 (0.45) | ADRA2AMCHR1MAPTMEN1NPC1 | |
| SCHEMBL6873057 | 0.92 | ALDH1A1 (0.45) | ADRA2AMCHR1MAPTMEN1NPC1 | |
| SCHEMBL6873527 | 0.91 | ADRA2A (0.46) | ADRA2AMCHR1MAPTMEN1NPC1 | |
| SCHEMBL6873523 | 0.91 | ADRA2A (0.46) | ADRA2AMCHR1MAPTMEN1NPC1 | |
| SCHEMBL6875749 | 0.90 | MAPT (0.46) | ADRA2AMCHR1MAPTMEN1KMT2A | |
| SCHEMBL6875743 | 0.90 | MAPT (0.46) | ADRA2AMCHR1MAPTMEN1KMT2A | |
| SCHEMBL6873429 | 0.87 | NPC1 (0.53) | ADRA2AMCHR1MAPTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |