Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868258 | 1.00 | ALDH1A1 (0.63) | ALDH1A1HTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL6460841 | 0.96 | ALDH1A1 (0.57) | ALDH1A1HTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL6460836 | 0.96 | ALDH1A1 (0.57) | ALDH1A1HTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL6876961 | 0.87 | L3MBTL1 (0.46) | ALDH1A1HTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL6876950 | 0.87 | L3MBTL1 (0.46) | ALDH1A1HTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL6463074 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HTTLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL6463067 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HTTLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL6878392 | 0.86 | LMNA (0.56) | ALDH1A1HTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL6878402 | 0.86 | LMNA (0.56) | ALDH1A1HTTLMNASMN1; SMN2TDP1 | |
| SCHEMBL6458640 | 0.85 | KMT2A (0.45) | ALDH1A1HTTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |