Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688357 | 0.91 | POLB (0.41) | MAPTMEN1KMT2APTGER3KDM4E | |
| SCHEMBL687369 | 0.90 | WDR5 (0.44) | MAPTMEN1KMT2APTGER3KDM4E | |
| SCHEMBL688264 | 0.90 | LCK (0.47) | MAPTMEN1KMT2APTGER3KDM4E | |
| SCHEMBL688110 | 0.89 | MEN1 (0.49) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL687932 | 0.88 | EGLN1 (0.44) | MAPTMEN1KMT2APTGER3KDM4E | |
| SCHEMBL687335 | 0.87 | CTSA (0.43) | CTSAPOLB | |
| SCHEMBL687511 | 0.87 | MEN1 (0.46) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL688277 | 0.87 | MEN1 (0.39) | MEN1KMT2AKDM4EALDH1A1CTSA | |
| SCHEMBL688248 | 0.87 | POLB (0.39) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL688548 | 0.86 | MAPT (0.64) | MAPTMEN1KMT2APTGER3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |