Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868513 | 1.00 | NPSR1 (0.50) | NPSR1ADRA2AMCHR1HRH1HTR2B | |
| SCHEMBL6878792 | 0.91 | SMN1; SMN2 (0.43) | NPSR1ADRA2AMCHR1HRH1HTR2B | |
| SCHEMBL6878795 | 0.91 | SMN1; SMN2 (0.43) | NPSR1ADRA2AMCHR1HRH1HTR2B | |
| SCHEMBL6878845 | 0.91 | SMN1; SMN2 (0.52) | ADRA2AMCHR1HRH1HTR2BSMN1; SMN2 | |
| SCHEMBL6878840 | 0.91 | SMN1; SMN2 (0.52) | ADRA2AMCHR1HRH1HTR2BSMN1; SMN2 | |
| SCHEMBL6878669 | 0.90 | SMN1; SMN2 (0.54) | NPSR1ADRA2AMCHR1HRH1HTR2B | |
| SCHEMBL6878673 | 0.90 | SMN1; SMN2 (0.54) | NPSR1ADRA2AMCHR1HRH1HTR2B | |
| SCHEMBL6875295 | 0.90 | MCHR1 (0.40) | NPSR1ADRA2AMCHR1HRH1HTR2B | |
| SCHEMBL6875288 | 0.90 | MCHR1 (0.40) | NPSR1ADRA2AMCHR1HRH1HTR2B | |
| SCHEMBL6456275 | 0.90 | SMN1; SMN2 (0.41) | NPSR1ADRA2AMCHR1HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |