Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 14/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 14/20 | 0.45 |
| ▸ | ACHE | P22303 | 14/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868628 | 1.00 | ADRA2A (0.46) | ADRA2ANPY5RMCHR1BCHECHRM1 | |
| SCHEMBL6871890 | 0.91 | CNR1 (0.52) | ADRA2AMCHR1BCHECHRM1ACHE | |
| SCHEMBL6871895 | 0.91 | CNR1 (0.52) | ADRA2AMCHR1BCHECHRM1ACHE | |
| SCHEMBL13793586 | 0.88 | MCHR1 (0.58) | ADRA2ANPY5RMCHR1P2RX7 | |
| SCHEMBL6875438 | 0.82 | MCHR1 (0.47) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL6875435 | 0.82 | MCHR1 (0.47) | ADRA2ANPY5RMCHR1 | |
| SCHEMBL27631579 | 0.82 | MCHR1 (0.50) | ADRA2ANPY5RMCHR1CHRM1CNR1 | |
| SCHEMBL6868191 | 0.82 | P2RX7 (0.45) | ADRA2ANPY5RMCHR1P2RX7KLKB1 | |
| SCHEMBL6868188 | 0.82 | P2RX7 (0.45) | ADRA2ANPY5RMCHR1P2RX7KLKB1 | |
| SCHEMBL6878748 | 0.81 | MCHR1 (0.49) | ADRA2ANPY5RMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |