Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878770 | 1.00 | ALDH1A1 (0.45) | ALDH1A1ALOX12SMN1; SMN2MCHR1LMNA | |
| SCHEMBL6463450 | 0.95 | MCHR1 (0.44) | SMN1; SMN2MCHR1LMNAKDM4ETP53 | |
| SCHEMBL6463465 | 0.95 | MCHR1 (0.44) | SMN1; SMN2MCHR1LMNAKDM4ETP53 | |
| SCHEMBL6872718 | 0.92 | ALOX12 (0.49) | ALDH1A1ALOX12SMN1; SMN2MCHR1LMNA | |
| SCHEMBL6872723 | 0.92 | ALOX12 (0.49) | ALDH1A1ALOX12SMN1; SMN2MCHR1LMNA | |
| SCHEMBL6465575 | 0.90 | TP53 (0.45) | ALDH1A1SMN1; SMN2MCHR1LMNAKDM4E | |
| SCHEMBL6465570 | 0.90 | TP53 (0.45) | ALDH1A1SMN1; SMN2MCHR1LMNAKDM4E | |
| SCHEMBL6879660 | 0.89 | MCHR1 (0.40) | SMN1; SMN2MCHR1LMNAKDM4ETP53 | |
| SCHEMBL6879666 | 0.89 | MCHR1 (0.40) | SMN1; SMN2MCHR1LMNAKDM4ETP53 | |
| SCHEMBL6877493 | 0.88 | TP53 (0.49) | ALDH1A1SMN1; SMN2MCHR1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |