Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 12/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866611 | 0.85 | LMNA (0.47) | MLYCDTACR1MAOBP2RX1TMPRSS4 | |
| SCHEMBL6016405 | 0.78 | TACR1 (0.52) | MLYCDTACR1P2RX1TMPRSS4 | |
| SCHEMBL6016431 | 0.74 | TACR1 (0.63) | TACR1 | |
| SCHEMBL7451868 | 0.73 | PDE10A (0.47) | — | |
| SCHEMBL6016400 | 0.71 | TACR1 (0.54) | TACR1P2RX1TMPRSS4 | |
| SCHEMBL4305835 | 0.70 | TACR1 (0.60) | MLYCDTACR1P2RX1TMPRSS4MTOR | |
| SCHEMBL25781485 | 0.68 | MLYCD (0.57) | MLYCDTACR1MAOBP2RX1TMPRSS4 | |
| SCHEMBL8544541 | 0.68 | JUN (0.67) | MLYCDTACR1MAOBP2RX1TMPRSS4 | |
| SCHEMBL6301053 | 0.68 | MTOR (0.58) | MLYCDTACR1MAOBP2RX1TMPRSS4 | |
| SCHEMBL25781486 | 0.68 | MLYCD (0.56) | MLYCDTACR1P2RX1TMPRSS4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187814-B1 | 5-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-08-18 | — | — | EP | disclosed |
| US-6756380-B1 | NEUROKININ 1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. | 2004-06-29 | — | — | US | disclosed |
| EP-1187814-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073278-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |