Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 6/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880977 | 0.92 | F10 (0.48) | ALDH1A1F10TPSAB1PRSS1F2 | |
| SCHEMBL9100846 | 0.91 | DDAH1 (0.44) | ALDH1A1MAPK1F10TPSAB1PRSS1 | |
| SCHEMBL6879854 | 0.81 | MAPT (0.42) | ALDH1A1KMT2AHDAC6HTTNPC1 | |
| SCHEMBL6879873 | 0.81 | MAPT (0.42) | ALDH1A1KMT2AHDAC6HTTNPC1 | |
| Hydrochloric Acid SCHEMBL11298541 | 0.80 | HDAC6 (0.44) | ALDH1A1POLBKMT2APRSS1PLAU | |
| SCHEMBL549168 | 0.78 | HDAC6 (0.39) | ALDH1A1POLBKMT2AF10PRSS1 | |
| SCHEMBL548419 | 0.77 | F10 (0.63) | F10TPSAB1PRSS1F2PLG | |
| SCHEMBL9028427 | 0.74 | F10 (0.48) | ALDH1A1F10TPSAB1PRSS1F2 | |
| SCHEMBL8677635 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPK1POLBKMT2AF10 | |
| SCHEMBL7483538 | 0.74 | F10 (0.44) | ALDH1A1MAPK1F10TPSAB1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6815461-B1 | ADMINISTERING BIS-BENZIMIDAZOLE COMPOUND; TREATING HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2004-11-09 | — | — | US | disclosed |
| EP-0739202-B1 | USE OF BIS(AMIDINOBENZIMIDAZOLES) IN THE MANUFACTURE OF MEDICAMENT FOR INHIBITING RETROVIRAL INTEGRASE | UNIV NORTH CAROLINA (US) | 1998-12-16 | — | — | EP | disclosed |