Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656762 | 0.82 | GABRA1 (0.54) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6519834 | 0.81 | HSD11B1 (0.44) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6775681 | 0.80 | HSD11B1 (0.43) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6775795 | 0.80 | DCTPP1 (0.45) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12794057 | 0.78 | GABRA1 (0.48) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6524041 | 0.77 | GABRA1 (0.47) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12794117 | 0.76 | GABRA1 (0.45) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6768851 | 0.76 | HSD11B1 (0.40) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6870403 | 0.75 | DCTPP1 (0.41) | HSD11B1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6527771 | 0.75 | GABRA1 (0.43) | HSD11B1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005520-A1 | DEUTERIUM-MODIFIED TRIAZOLO-PYRIDAZINE DERIVATIVES AS GABA-A RECEPTOR MODULATORS | CONCERT PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |