Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870471 | 0.89 | NPC1 (0.43) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6868240 | 0.88 | MAPT (0.43) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6871096 | 0.87 | MAPT (0.42) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6871316 | 0.83 | TP53 (0.42) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6870831 | 0.83 | MAPT (0.40) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6866143 | 0.83 | MAPT (0.46) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6871117 | 0.81 | DHPS (0.41) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6016493 | 0.79 | EGFR (0.40) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6868237 | 0.78 | TP53 (0.41) | NPC1RAB9AKMT2AMEN1TLR9 | |
| SCHEMBL6868792 | 0.78 | MITF (0.44) | NPC1RAB9AKMT2AMEN1TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187814-B1 | 5-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-08-18 | — | — | EP | disclosed |
| US-6756380-B1 | NEUROKININ 1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. | 2004-06-29 | — | — | US | disclosed |
| EP-1187814-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073278-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |