Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6871570 | 0.90 | HPGD (0.46) | MAPTALDH1A1CYP3A4LMNAKDM4E | |
| SCHEMBL6869899 | 0.90 | SLC16A3 (0.43) | KMT2AMAPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6867499 | 0.89 | KMT2A (0.43) | KMT2AMAPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6863086 | 0.88 | PLAU (0.44) | ALDH1A1CYP2D6ADORA2ALMNAKDM4E | |
| SCHEMBL6873046 | 0.83 | ADORA2A (0.56) | KMT2AMAPTALDH1A1ADORA2APRNP | |
| SCHEMBL6873034 | 0.83 | ADORA2A (0.39) | MAPTALDH1A1ADORA2ALMNAKDM4E | |
| SCHEMBL6872062 | 0.82 | TP53 (0.47) | KMT2AMAPTALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6870074 | 0.81 | KMT2A (0.48) | KMT2AMAPTALDH1A1CYP3A4ADORA2A | |
| SCHEMBL6867527 | 0.81 | ADORA2A (0.38) | KMT2AMAPTALDH1A1ADORA2ALMNA | |
| SCHEMBL6869624 | 0.81 | ADORA2A (0.41) | KMT2AMAPTALDH1A1CYP3A4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |