Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863144 | 0.96 | NAAA (0.39) | ADORA2AMAPTALOX15NPC1RAB9A | |
| SCHEMBL6873034 | 0.94 | ADORA2A (0.39) | ADORA2AMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6871700 | 0.88 | SMN1; SMN2 (0.41) | ADORA2ASMN1; SMN2EGLN2ALOX15KDR | |
| SCHEMBL6863086 | 0.84 | PLAU (0.44) | ADORA2ASMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL6871503 | 0.83 | ADORA2A (0.43) | ADORA2AMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6872018 | 0.83 | ADORA2A (0.41) | ADORA2AMAPTALDH1A1LMNANPC1 | |
| SCHEMBL6871570 | 0.82 | HPGD (0.46) | MAPTHPGDALDH1A1LMNAKDM4E | |
| SCHEMBL6863519 | 0.82 | ADORA2A (0.44) | ADORA2ASMN1; SMN2HPGDALDH1A1NPC1 | |
| SCHEMBL6870384 | 0.82 | ADORA2A (0.58) | ADORA2AMAPTSMN1; SMN2EGLN2ALOX15 | |
| SCHEMBL6869899 | 0.81 | SLC16A3 (0.43) | MAPTSMN1; SMN2HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |