Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.42 |
| ▸ | WNT3A | P56704 | 3/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800434 | 0.82 | MAPT (0.55) | RAB9ANPC1PKMCTNNB1WNT3A | |
| SCHEMBL4517760 | 0.78 | CTNNB1 (0.59) | RAB9ANPC1PKMPRKCITAS1R3 | |
| SCHEMBL6794849 | 0.78 | CTNNB1 (0.48) | RAB9ANPC1PKMPRKCITAS1R3 | |
| SCHEMBL4511538 | 0.76 | PRKCI (0.51) | RAB9ANPC1PKMPRKCITAS1R3 | |
| SCHEMBL11237187 | 0.74 | PRKCI (0.60) | RAB9ANPC1PRKCITAS1R3TAS1R1 | |
| SCHEMBL2237588 | 0.73 | P2RX7 (0.62) | RAB9ANPC1MAPTHPGD | |
| SCHEMBL29793780 | 0.73 | PRKCI (0.62) | RAB9ANPC1PRKCITAS1R3TAS1R1 | |
| SCHEMBL102518 | 0.73 | PRKCI (0.62) | RAB9ANPC1PRKCITAS1R3TAS1R1 | |
| SCHEMBL11022359 | 0.72 | PRKCI (0.66) | RAB9ANPC1PRKCITAS1R3TAS1R1 | |
| SCHEMBL2495453 | 0.72 | TAS1R3 (0.53) | RAB9ANPC1PRKCITAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220230-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. | 2004-11-04 | — | — | US | disclosed |
| US-20030166633-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-09-04 | — | — | US | disclosed |
| EP-1257543-A1 | PYRIDINYLIMIDAZOLES | SMITHKLINE BEECHAM PLC (GB) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001062756-A1 | PYRIDINYLIMIDAZOLES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166633-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | RAB9A 1665/4885NPC1 1966/4885PKM 1260/4885 |
| US-20040220230-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | RAB9A 1614/4885NPC1 1327/4885PKM 1036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.