Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.44 |
| ▸ | RBP4 | P02753 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930654 | 0.86 | PARP1 (0.52) | HRH4PARP1PDE10ARBP4 | |
| SCHEMBL2236950 | 0.79 | HRH4 (0.69) | HRH4PARP1PDE10ARBP4 | |
| SCHEMBL6874575 | 0.77 | HRH4 (0.55) | HRH4PDE10A | |
| SCHEMBL30396672 | 0.74 | HRH4 (0.47) | HRH4PDE10A | |
| SCHEMBL15064410 | 0.74 | PDE10A (0.59) | HRH4PDE10ARBP4 | |
| SCHEMBL27552206 | 0.74 | XDH (0.52) | HRH4 | |
| SCHEMBL7465456 | 0.73 | PDE10A (0.56) | HRH4PARP1PDE10ARBP4 | |
| SCHEMBL26384460 | 0.72 | YAP1 (0.41) | PARP1 | |
| SCHEMBL2227562 | 0.72 | DRD2 (0.42) | HRH4PDE10A | |
| SCHEMBL24067409 | 0.72 | HTR2B (0.59) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |