Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877522 | 1.00 | ACHE (0.36) | ACHEBACE1MCHR1ADRA2AHRH1 | |
| SCHEMBL6875559 | 0.86 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879311 | 0.83 | MAPK8 (0.43) | ACHEBACE1MCHR1ADRA2AMAPK8 | |
| SCHEMBL6879316 | 0.83 | MAPK8 (0.43) | ACHEBACE1MCHR1ADRA2AMAPK8 | |
| SCHEMBL6875096 | 0.81 | MCHR1 (0.37) | ACHEBACE1MCHR1ADRA2AHRH1 | |
| SCHEMBL6875101 | 0.81 | MCHR1 (0.37) | ACHEBACE1MCHR1ADRA2AHRH1 | |
| SCHEMBL6873935 | 0.79 | ACHE (0.38) | ACHEBACE1MAPK8MAPK9MAPK10 | |
| SCHEMBL6873931 | 0.79 | ACHE (0.38) | ACHEBACE1MAPK8MAPK9MAPK10 | |
| SCHEMBL6464494 | 0.79 | CTSK (0.41) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873078 | 0.78 | TSHR (0.51) | ACHEBACE1MCHR1ADRA2AMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |