Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 17/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687425 | 0.82 | ILK (0.73) | ILKAPP | |
| SCHEMBL2165867 | 0.81 | ILK (0.72) | ILK | |
| SCHEMBL687793 | 0.78 | ILK (0.49) | ILKCA2 | |
| SCHEMBL686413 | 0.77 | ILK (0.74) | ILKKMT2A | |
| SCHEMBL687116 | 0.77 | ILK (0.70) | ILKAPP | |
| SCHEMBL686420 | 0.77 | ILK (0.70) | ILKAPP | |
| SCHEMBL687684 | 0.77 | ILK (0.70) | ILKAPP | |
| SCHEMBL686498 | 0.77 | ILK (0.60) | ILK | |
| SCHEMBL686512 | 0.77 | ILK (0.52) | ILK | |
| SCHEMBL686543 | 0.76 | ILK (0.73) | ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | claimed |