Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 17/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687029 | 0.83 | ILK (0.49) | ILKNPC1PKMNFKB1RAB9A | |
| SCHEMBL686489 | 0.81 | ILK (0.72) | ILKNPC1RAB9A | |
| SCHEMBL687221 | 0.78 | ILK (0.53) | ILKCA2 | |
| SCHEMBL686934 | 0.76 | ILK (0.70) | ILKCA2NPC1RAB9A | |
| SCHEMBL687102 | 0.75 | ILK (0.72) | ILK | |
| SCHEMBL686453 | 0.74 | ILK (0.70) | ILK | |
| SCHEMBL687608 | 0.73 | ILK (0.55) | ILK | |
| SCHEMBL7163781 | 0.72 | CA2 (0.51) | CA2NPC1PKMNFKB1RAB9A | |
| SCHEMBL686809 | 0.71 | ILK (0.72) | ILK | |
| SCHEMBL2165867 | 0.71 | ILK (0.72) | ILKNPC1NFKB1RAB9ANFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | claimed |