Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884826 | 0.81 | TDP1 (0.58) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL4730798 | 0.78 | TDP1 (0.47) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL10584699 | 0.78 | TDP1 (0.54) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL30134334 | 0.76 | TDP1 (0.62) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL47807 | 0.76 | TDP1 (0.62) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL27853484 | 0.76 | TDP1 (0.72) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL6933536 | 0.74 | ALDH1A1 (0.46) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL47808 | 0.74 | TDP1 (0.65) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL31304747 | 0.74 | TDP1 (0.65) | TDP1ATMBCHEALDH1A1TSHR | |
| SCHEMBL6403938 | 0.74 | TDP1 (0.60) | TDP1ATMBCHEALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6822089-B1 | FROM CORRESPONDING RIBONUCLEOSIDES BY FORMING 3-TERT-BUTYLPHENOXYTHIOCARBONYL DERIVATIVES AND EFFECTING RADICAL DEOXYGENATION; SOLID PHASE SYNTHESIS | ISIS PHARMACEUTICALS, INC. | 2004-11-23 | — | — | US | claimed |
| EP-1366056-A2 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 2003-12-03 | — | — | EP | claimed |
| EP-1366056-A4 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2003-12-03 | — | — | EP | claimed |
| WO-2001073095-A2 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | WO | claimed |
| US-6822089-B1 | FROM CORRESPONDING RIBONUCLEOSIDES BY FORMING 3-TERT-BUTYLPHENOXYTHIOCARBONYL DERIVATIVES AND EFFECTING RADICAL DEOXYGENATION; SOLID PHASE SYNTHESIS | ISIS PHARMACEUTICALS, INC. | 2004-11-23 | — | — | US | disclosed |
| EP-1366056-A2 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-1366056-A4 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2001073095-A2 | PREPARATION OF DEOXYNUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | WO | disclosed |