Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9351809 | 0.84 | ADRA2A (0.40) | L3MBTL1ALDH1A1KMT2ARXRARXRB | |
| SCHEMBL6872602 | 0.78 | TDP1 (0.50) | TDP1ATMALDH1A1KDM4EBCHE | |
| SCHEMBL13158912 | 0.76 | ALDH1A1 (0.39) | TDP1ATML3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24813703 | 0.76 | TP53 (0.48) | TDP1ATML3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10584699 | 0.75 | TDP1 (0.54) | TDP1ATMALDH1A1KDM4EBCHE | |
| SCHEMBL22829872 | 0.74 | FABP7 (0.37) | L3MBTL1ALDH1A1BCHETSHRMAPT | |
| SCHEMBL27269441 | 0.74 | NR1I2 (0.52) | TDP1ATMALDH1A1KDM4EBCHE | |
| SCHEMBL10932562 | 0.74 | TDP1 (0.36) | TDP1ATMALDH1A1KDM4EBCHE | |
| SCHEMBL47807 | 0.73 | TDP1 (0.62) | TDP1ATMALDH1A1KDM4EBCHE | |
| SCHEMBL30134334 | 0.73 | TDP1 (0.62) | TDP1ATMALDH1A1KDM4EBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| US-5359065-A | Reacting a bromo aromatic compound with an excess of silylating agent; forming metallized intermediate; quenching | EASTMAN KODAK COMPANY (US) | 1994-10-25 | — | — | US | disclosed |