Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873456 | 1.00 | MEN1 (0.48) | MEN1KMT2ASIGMAR1MCHR1ADRA2A | |
| SCHEMBL6873183 | 0.91 | MAPT (0.43) | MEN1KMT2ASIGMAR1MCHR1ADRA2A | |
| SCHEMBL6873188 | 0.91 | MAPT (0.43) | MEN1KMT2ASIGMAR1MCHR1ADRA2A | |
| SCHEMBL6875761 | 0.88 | MCHR1 (0.41) | MEN1KMT2AMCHR1ADRA2AMAPT | |
| SCHEMBL6459434 | 0.88 | MCHR1 (0.41) | MEN1KMT2AMCHR1ADRA2AMAPT | |
| SCHEMBL6457880 | 0.87 | EPHX2 (0.55) | SIGMAR1MCHR1ADRA2AMAPTRAB9A | |
| SCHEMBL6457869 | 0.87 | EPHX2 (0.55) | SIGMAR1MCHR1ADRA2AMAPTRAB9A | |
| SCHEMBL6878654 | 0.87 | SIGMAR1 (0.47) | MEN1KMT2ASIGMAR1MCHR1ADRA2A | |
| SCHEMBL6878649 | 0.87 | SIGMAR1 (0.47) | MEN1KMT2ASIGMAR1MCHR1ADRA2A | |
| SCHEMBL6873945 | 0.86 | MCHR1 (0.44) | KMT2AMCHR1ADRA2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |